Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

Search Within Results

2,056 – 2,070 of 5,426 results

2,056

Apexbio Technology LLC AZ5104 1421373-98-9 200mg

AZ5104 (CAS 1421373-98-9) is a demethylated metabolite of AZD9291 functioning as a potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase It exhibits high affinity for mutant EGFR forms with IC50 values below 1 nM for EGFR L858R/T790M 6 nM for EGFR L858R 1 nM for EGFR L861Q and 25 nM for wild-type EGFR Compared to AZD9291 AZ5104 demonstrates increased potency in cellular models harboring EGFR ex19del (PC-9) T790M (H1975) and wild-type EGFR (LOVO) In vivo oral administration in mice led to a plasma metabolite level of 33% at 3 hours post-dose and 5 mg/kg/day reduced tumor growth in relevant models AZ5104 serves as a valuable tool for studying EGFR-driven cancer mechanisms and resistance

Pricing & Availability

2,057

Apexbio Technology LLC Proflavine Hemisulfate 1811-28-5 10mM (in 1mL DMSO)

Proflavine Hemisulfate (CAS 1811-28-5) is a small-molecule inhibitor targeting DNA It is designed to intercalate into DNA strands thereby disrupting DNA replication and transcription Proflavine Hemisulfate exerts its biological activity primarily through DNA intercalation In in vitro studies Proflavine Hemisulfate demonstrates antimicrobial activity with reported IC50 values for inhibiting bacterial growth typically ranging between 1 10 M depending on the microbial strain and assay conditions used Based on these pharmacological properties Proflavine Hemisulfate holds research potential in studies of antimicrobial activity DNA replication assays mutagenesis and evaluating sensitivity and resistance profiles of microorganisms

Pricing & Availability

2,058

Apexbio Technology LLC ASP3026 1097917-15-1 200mg

ASP3026 (CAS 1097917-15-1) is a selective inhibitor of anaplastic lymphoma kinase (ALK) exhibiting an IC50 of 3 5 nM for ALK enzymatic inhibition When evaluated across a panel of 86 tyrosine kinases ASP3026 demonstrated highest selectivity for ALK ROS and ACK kinases In cellular studies ASP3026 inhibited the proliferation of EML4-ALK-expressing NCI-H2228 non-small cell lung cancer (NSCLC) cells (IC50 64 8 nM) and reduced viability in NPM-ALK anaplastic large cell lymphoma (ALCL) lines with IC50 values ranging from 0 4 to 2 5 M In vivo oral administration of ASP3026 in mouse xenograft models suppressed ALK phosphorylation and significantly reduced tumor growth ASP3026 serves as a valuable tool for investigating ALK-driven oncogenesis and for preclinical evaluation of ALK-targeted therapies

Pricing & Availability

2,059

Apexbio Technology LLC 10-DAB (10-Deacetylbaccatin) 32981-86-5 200mg

10-Deacetylbaccatin is a diterpenoid intermediate used as a precursor in the synthesis of chemotherapeutic agents such as paclitaxel and docetaxel It serves as a starting framework for the chemical transformation into taxane-based antitumor compounds 10-Deacetylbaccatin exerts its value primarily through its utility in medicinal chemistry for developing and optimizing cancer therapeutics Based on these properties 10-Deacetylbaccatin holds research potential in the field of cancer drug development

Pricing & Availability

2,060

Apexbio Technology LLC Tandutinib (MLN518) 387867-13-2 200mg

Tandutinib (MLN518 CAS 387867-13-2) is a selective small molecule inhibitor primarily targeting FLT3 with additional activity against PDGFR and c-Kit In biochemical kinase assays Tandutinib exhibits IC50 values of 0 22 M for FLT3 0 20 M for PDGFR and 0 17 M for c-Kit It effectively inhibits tyrosine phosphorylation of both wild-type FLT3 and FLT3 mutants with IC50 values in the 30 100 nM range In cellular models Tandutinib demonstrates anti-proliferative effects in FLT3-ITD-positive cell lines (Molm-13 Molm-14) at low nanomolar concentrations whereas FLT3-ITD-negative cells are substantially less sensitive This compound is utilized in research investigating FLT3-mediated signaling and acute myelogenous leukemia (AML) pathogenesis

Pricing & Availability

2,061

Apexbio Technology LLC Quinine HCl Dihydrate 6119-47-7 10mM (in 1mL DMSO)

Quinine HCl Dihydrate is a quinoline alkaloid hydrochloride salt presented as a dihydrate form It exerts its biological activity primarily through interference with heme detoxification mechanisms within Plasmodium species disrupting parasite-mediated heme metabolism and inducing cytotoxic free heme accumulation At the molecular level quinoline derivatives may inhibit nucleic acid synthesis affecting DNA replication and transcription events during erythrocytic lifecycle stages Researchers frequently utilize Quinine HCl Dihydrate for studies on antimalarial drug mechanisms parasite resistance pathways and as a reference standard in pharmacological and pharmacokinetic assessments

Pricing & Availability

2,062

Apexbio Technology LLC RU.521 2262452-06-0 25mg

RU 521 (CAS 2262452-06-0) is a selective inhibitor of cyclic GMP-AMP synthase (cGAS) an enzyme responsible for synthesizing cGAMP upon recognition of cytosolic double-stranded DNA By interfering with cGAS-mediated cGAMP production RU 521 suppresses activation of the type I interferon signaling pathway Experimental studies demonstrate that RU 521 reduces cGAS-dependent signal transduction and interferon responses in reporter assays containing double-stranded DNA In macrophages derived from Aicardi-Gouti res syndrome mouse models RU 521 lowers basal interferon expression This compound is a valuable tool for investigating cGAS-dependent innate immune pathways

Pricing & Availability

2,063

eMolecules 24782-64-7 | 9-OXO-9,10-DIHYDROACRIDINE-4-CARBOXYLIC ACID | AstaTech | MFCD00957937 | 239.230 | C14H9NO3 | 95.000 | OC(=O)c1cccc2c1[nH]c1ccccc1c2=O | 1g | 552878994

9-OXO-9,10-DIHYDROACRIDINE-4-CARBOXYLIC ACID | AstaTech | 24782-64-7 | MFCD00957937 | 239.230 | C14H9NO3 | 95.000 | OC(=O)c1cccc2c1[nH]c1ccccc1c2=O | 1g | 552878994

Pricing & Availability

2,064

eMolecules 4,8-Dimethyl-2-quinolinol | 5349-78-0 | MFCD00085676 | 1g

Matrix Scientific | 4,8-Dimethyl-2-quinolinol | 1g | 389720509 | 44181 | 95.000 | 5349-78-0 | MFCD00085676 | 173.215 | C11H11NO

If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool

Pricing & Availability

2,065

eMolecules 1261462-15-0 | 5-HYDROXYQUINOLINE-4-CARBOXYLIC ACID | MFCD18417134 | 1g

Ambeed | (S)-5-Benzyl-5-azaspiro[2.4]heptan-7-amine | 100mg | 650570763 | A827644 | 144282-35-9 | MFCD17926316 | 202.301 | C13H18N2

If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool<|a>

Pricing & Availability

2,066

eMolecules 1379345-02-4 | 4-BROMO-8-NITROQUINOLINE | MFCD08688610 | 1g

Ambeed | Ethyl 2-amino-1-methyl-1H-imidazole-5-carboxylate | 250mg | 552662731 | A229412 | 177760-04-2 | MFCD09997799 | 169.184 | C7H11N3O2

If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool<|a>

Pricing & Availability

2,067

eMolecules 770711-44-9 | 3-QUINOLINECARBOXYLIC ACID, 1,2-DIHYDRO-4-HYDROXY-2-OXO-1-PHENYL-, METHYL ESTER | MFCD13192026 | 1g

AstaTech | 3-QUINOLINECARBOXYLIC ACID, 1,2-DIHYDRO-4-HYDROXY-2-OXO-1-PHENYL-, METHYL ESTER | 1g | 335881458 | P16636 | 98.000 | 770711-44-9 | MFCD13192026 | 295.294 | C17H13NO4

If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool<|a>