Quinolines and derivatives
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Filtered Search Results
Environmental Sampling Supply Inc ENVIRONMENTAL SAMPLING SUPPLY INC
NC3897147 40ML AOT/25MG ASCB/200MG MALC
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Medchemexpress LLC Quinidine (15% dihydroquinidine) | 56-54-2 | 98.36% | 5 G
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Quinidine (15% dihydroquinidine) is an antiarrhythmic agent. It is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine also acts as a K+ channel blocker with an IC50 of 19.9 μM, and it can induce apoptosis. It can be used for malaria research.
- Antiarrhythmic agent: Helps in the treatment of irregular heartbeats.
- Potent, orally active, selective cytochrome P450db inhibitor: Targets and inhibits specific cytochrome P450 enzymes.
- K+ channel blocker: Blocks potassium channels with an IC50 of 19.9 μM.
- Induces apoptosis: Capable of triggering programmed cell death.
- Used for malaria research: Applicable in studies related to malaria.
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Medchemexpress LLC CI-1040 (PD 184352) | 212631-79-3 | 99.9% | C17H14ClF2IN2O2 | 200 MG
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CI-1040 (PD 184352) is an orally active, highly specific, small-molecule inhibitor of MEK with an IC50 of 17 nM for MEK1. It is intended for research use only, exhibiting potent MEK1 inhibition and minimal activity against related kinases. It completely inhibits mitogen-stimulated ERK phosphorylation in whole cells.
- Directly inhibits MEK1 with high specificity
- Induces apoptosis and inhibits proliferation
- Increases PUMA mRNA and protein levels
- Reduces adenoma formation in lung cancer models
- Decreases lung cell proliferation
- Shows antiproliferative activity in various cancer cell lines
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Ambeed 1 3 4Oxadiazol2amine
1,3,4-Oxadiazol-2-amine, 3775-60-8, 95%
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Medchemexpress LLC 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine | 103285-22-9 | 98.0% | 560.59 g/mol | C31H32N2O8 | 1 G
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5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine is a DMT-protected uridine nucleoside analog with a 2'-O-methyl ribose modification, used as an intermediate in the chemical synthesis of modified oligonucleotides and nucleoside derivatives. Molecular formula C31H32N2O8; molecular weight 560.59 g/mol. Follow supplier storage recommendations for long-term stability.
- DMT-protected at the 5'-position for controlled deprotection.
- 2'-O-methyl modification enhances nuclease resistance.
- Designed for incorporation into synthetic oligonucleotides.
- High purity (98.0%) suitable for research applications.
- Stable as a powder under recommended storage conditions.
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Medchemexpress LLC NP118809 | 41332-24-5 | 98.73% | C₃₂H₃₂N₂O | 200 MG
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NP118809 is a potent N-type calcium channel blocker with an IC₅₀ of 0.11 μM, and also inhibits L-type calcium channels less potently with an IC₅₀ of 12.2 μM. It is intended for research use only.
- Potent N-type calcium channel blocker (IC₅₀ of 0.11 μM).
- Inhibits L-type calcium channels (IC₅₀ of 12.2 μM).
- Shows significant analgesic activity in the phase IIA portions of the rat formalin model (25 mg/kg, i.p.).
- Results in 80.3% inhibition of mechanical allodynia and 96.3% inhibition of thermal hyperalgesia in the rat spinal nerve ligation model (30 mg/kg, p.o.).
- Available in solid form, light yellow to yellow in color.
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Medchemexpress LLC Benzyl-PEG5-amine | 86770-77-6 | 98.0% | C17H29NO5 | 250 MG
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Benzyl-PEG5-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs (Proteolysis Targeting Chimeras) consist of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets the protein intended for degradation. They leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- Used in PROTAC synthesis
- PEG-based linker
- Facilitates selective protein degradation
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Ambeed 3 4Chlorophenyl N pyridin4ylme
3-(4-Chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide, 915385-81-8, 98%
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Chemscene CHEMSCENE
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5000577953 2-OXO-1 2-DIHYDROQUINOLINE- 5G
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Chemscene CHEMSCENE
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5000578560 N-BENZYLNAPHTHALEN-2-AMINE 5G
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Apexbio Technology LLC LY2886721 1262036-50-9 200mg
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LY2886721 (CAS 1262036-50-9) is an orally bioavailable inhibitor of -site amyloid precursor protein cleaving enzyme 1 (BACE1) an aspartyl protease integral to amyloid precursor protein (APP) cleavage and amyloid- (A ) generation LY2886721 inhibits BACE1 activity with an IC50 of approximately 20 3 nM effectively reducing soluble APP and elevating soluble APP in human cell models (HEK293Swe) and neuronal cultures (PDAPP) at IC50 values of 18 7 nM and 10 7 nM respectively In animal models such as PDAPP mice oral LY2886721 administration dose-dependently reduces cerebral A C99 and sAPP levels Due to its BACE1 inhibitory action LY2886721 serves as a valuable tool in Alzheimer s disease research and therapeutic development
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TARGETMOL CHEMICALS INC OPAVIRALINE 5MG
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Opaviraline (GW-420867X) is a potent reverse transcriptase inhibitor that inhibits Human immunodeficiency virus 1 and has the potential to treat HIV infection. purity: 100%
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Ambeed R 4Benzyl2oxazolidinone
(R)-4-Benzyl-2-oxazolidinone, 102029-44-7, 98%
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Medchemexpress LLC Amine-PEG3-lys(PEG3-N3)-PEG3-N3 | 2244602-35-3 | 98.0% | 750.84 g/mol | C30H58N10O12 | 100 MG
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Amine-PEG3-Lys(PEG3-N3)-PEG3-N3 is a branched polyethylene glycol (PEG) linker designed for use in the synthesis of antibody-drug conjugates (ADCs). It features an amine terminus and multiple PEG3 spacers terminated with azide (N3) groups to enable orthogonal conjugation strategies.
- Branched PEG linker with amine and azide functional groups.
- Designed for ADC synthesis and bioconjugation.
- Multiple PEG3 spacers increase solubility and flexibility.
- Enables orthogonal conjugation via amine and azide chemistries.
- Typical reported purity 98.0%.
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Medchemexpress LLC Sulfo-Cy3(Me)COOH | 1121756-11-3 | 95.0% | 616.75 g·mol⁻¹ | C30H36N2O8S2 | 10 MG
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Sulfo-Cy3(Me)COOH is a sulfonated cyanine3 derivative supplied as a green to dark green solid. It is an orange-fluorescent labeling reagent for proteins and nucleic acids, with excitation at ~554 nm and emission at ~568 nm. The compound is water-soluble and is provided at 10 mg with high purity, intended for conjugation and fluorescence assay applications and requiring protection from light.
- Orange-fluorescent label: Ex = 554 nm, Em = 568 nm.
- High purity suitable for conjugation: ~95.0%.
- Water-soluble: H2O solubility 125 mg/mL (ultrasonic may be required).
- Appearance: solid, green to dark green.
- Storage: 4°C protected from light; in solvent -80°C (6 months) or -20°C (1 month).
- Typical applications: labeling of proteins and nucleic acids, fluorescence assays, conjugation chemistry.
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